The smoke-free Depiero Hotel Karakoey Istanbul is located around 10 minutes' walk from Istanbul Riverside Museum of Modern Art and provides tour/ticket assistance for a better travel experience. This 4-star hotel is situated in the centre of Istanbul, within easy reach of such cultural attractions as The Quincentennial Foundation Jewish Museum of Turkish Jews.

The Kilic Ali Pasha Complex is merely 1.1 km from the hotel, while Gülhane Park is 2.3 km away. Guests can visit the Neve Shalom Synagogue, which is only 6 minutes' walk away, and the highway Ataturk Bridge which is not far from the Depiero Istanbul. Standing 2.7 km away, the great Hagia Sophia Museum is a hard-to-miss divine tourist destination. The property is about 600 metres from Azapkapi-Golden Horn Underground bus stop and about 10 minutes on foot from Sishane-Zemin Istanbul tube station.

There are 20 rooms at Depiero Hotel Karakoey, each of them has climate control, as well as entertainment amenities such as a flat-screen TV with satellite channels. Along with a separate toilet and a shower, bathroom comforts also include hairdryers and bath sheets.

A buffet breakfast is offered to guests daily. The Depiero is a short way from Yildizlar Restaurant serving European dishes.