Grand Marcello Hotel Istanbul features 50 rooms and lies a 25-minute walk from the large Topkapi Palace harem Museum. Located in close proximity to the Ottoman imperial Pertevniyal Valide Sultan Mosque, this hotel overlooks the city and invites guests to have a drink at a lounge bar.

The comfortable hotel boasts a comfortable location in Golden Horn, which is a natural harbour off the strait, within 500 metres of Beyazıt Square. The Grand Marcello also gives access to the Holy mosque "Hagia Sophia Museum", which is a 30-minute walk away. This property is 2.8 km from Istanbul Riverside Museum of Modern Art. The 4-star hotel is situated 10 minutes' stroll from Vezneciler-İstanbul Üniversitesi underground station and a short way from Yenikapi train station.

The air-conditioned rooms at the family-friendly Grand Marcello Hotel feature blackout drapes and individual climate control along with a mini fridge bar and tea/coffee making equipment. Bathrooms include a separate toilet and a shower, and such comforts as hair dryers and bath sheets.

Every day a free buffet breakfast is served. Guests may find the seafood restaurant Byzantion Bistro & Restaurant 250 metres away.