Located in an old part of Istanbul and about km from Golden Horn, the smoke-free Meddusa Hotel Istanbul offers bicycle and car rentals to help guests explore the area. Boasting a location within a few blocks of the ancient Sultanahmet District, the 2-star hotel offers 16 rooms and a 24-hour bar onsite.

The hotel is situated 17 minutes' walk from Beyazıt Square, while the sultan Ahmed Blue Mosque is only 8 minutes' walk away. The Meddusa is right near the palace Museum of Turkish and Islamic Arts and 45 km from Istanbul Sabiha Gokcen International airport. Guests will also appreciate the vicinity to Sea of Marmara, which is approximately 1 km away. The property is within 25 minutes' walk of the Ottoman imperial Suleymaniye Mosque. Meddusa Hotel is located a few steps from Sirkeci train station, while Big Tours Istanbul bus stop is 300 metres away.

Some of the air-conditioned rooms have a mini-kitchen and a dining area, and such facilities as high-speed internet and a flat-screen TV, along with coffee and tea making equipment. Also, they feature marble flooring. Most rooms offer views of the garden. Looking onto the garden, the studio suite features kitchenette with coffee/tea makers, a refrigerator, and kitchenware.

A free buffet breakfast is offered each morning at the Meddusa Istanbul. The small bar is also available. Serving healthy meals, Buhara Ocakbasi Restaurant lies just around the corner from this Istanbul hotel.