Offering a restaurant, the comfortable Meryem Ana Hotel Istanbul lies in European Side with Istanbul's old center, with classic sights like opulent Topkapı Palace, the Blue Mosque, and Hagia Sophia, a mosque famed for its Byzantine mosaics, just 1.3 km from the private Pera Museum and approximately 10 minutes' drive from Ciragan Palace Kempinski.

The 3-star hotel is notable for its convenient location, within 5 minutes' walk of the cobblestone Istiklal Street and within 3 km of Sirkeci train station. This Istanbul hotel is around 100 metres from Taksim Meydan bus stop and within easy reach of Republic Monument. The large Topkapi Palace harem Museum is nearly 15 minutes away by car, while Taksim underground station is in close proximity to the Meryem Ana Istanbul. Guests will find Taskisla cable car station just 0.8 km from the accommodation.

Air conditioning are among the comforts available in the comfortable rooms. There is also a private bathroom.

Turkish cuisine is offered at Hafiz Mustafa 1864, situated near Meryem Ana Hotel.