Offering luggage storage, Otel Grand Sami Istanbul lies in Golden Horn, which is a natural harbour off the strait, nearly 25 minutes' walk from Church of the Monastery of Christ Pantokrator and a mere 1.6 km from the functioning Blue Mosque. This Istanbul hotel features safety facilities including a safety deposit box and 24-hour security service.

Istanbul Photography Museum is located just 450 metres from the hotel, and such natural sites as the historical urban Gulhane Park are around 2 km away. The area includes such religious sights as the ornate 16th - century Suleymaniye Mosque (1.5 km) and the 4th - century Byzantine Hagia Irene Church Museum (2.1 km). The great Hagia Sophia Museum lies about a 20-minute walk away, while Vezneciler-İstanbul Üniversitesi tube station is a short way from the Otel Grand Sami Istanbul. The accommodation is just 450 metres from Laleli bus stop and within a 1-km distance of Yenikapi train station in Istanbul.

Guests can also enjoy Turkish food at Sadik Usta'nin Yeri located right near the hotel.