Offering a storage for belongings, Otel Grand Sami Istanbul lies in Golden Horn, which is a natural harbour off the strait, 16 minutes' stroll from the Serpent Column and a mere 1.7 km from the great Hagia Sophia Museum. This Istanbul hotel has views of the sea and features Wi-Fi throughout the property.

The Istanbul Photography Museum is located only 6 minutes' walk from the hotel, and such natural sites as the historical urban Gulhane Park are approximately a 25-minute walk away. Pampering its guests with wellness experiences, Cagaloglu Hamami Public Bath is within reach of the Otel Grand Sami Istanbul. The Basilica Cistern lies just 1.6 km away, and Vezneciler-İstanbul Üniversitesi tube station is about 700 metres from the accommodation. This Istanbul hotel is right near Laleli bus stop.

The air-conditioned rooms in Otel Grand Sami have a flat screen TV along with an air conditioner. Appointed with a parquet floor, the rooms also come with an electric kettle.

Guests may find the restaurant Han Atlas Uzbek Restaurant around 5 minutes on foot from the property.