Offering a restaurant, Sami Hotel Istanbul lies in Golden Horn, which is a natural harbour off the strait, just 1.6 km from the Ottoman Rustem Pasha Mosque and within 25 minutes' walk of such cultural places of interest as the large Topkapi Palace harem Museum. This Istanbul hotel also entices guests with shuttle service.

The Istanbul Photography Museum is located merely 450 metres from the hotel, and such natural sites as Miniaturk Miniature Park are around 7 km away. The Sami Istanbul provides easy access to the l6th - century Sokullu Mehmed Pasa Mosque, which is only 13 minutes' walk away. The word Sultanahmet District lies just 1.5 km away, while Vezneciler-İstanbul Üniversitesi tube station is a short way from the property. The hotel provides a place to stay nearly 10 minutes' walk from the Yenikapi Aktarma Merkezi train station.

Situated just around the corner from Sami Hotel, the restaurant Han Atlas Uzbek Restaurant offers a Central Asian menu.