Located 10 minutes by car from Basilica Cistern, Hotel Santa Beyoglu Istanbul is within a 500-metre distance of Church of Saint Anthony of Padua.

Beyoglu is a 7-minute walk away, while Sirkeci train station is 2.8 km from this hotel. The 3-star hotel stands in the vicinity of Hagia Triada Greek Orthodox Church. Guests might as well visit Palazzo Venezia, which is 1 km away. There is the ancient Sultanahmet District a 15-minute ride away, and Tarlabasi bus station is a 10-minute walk from the Santa Beyoglu. Offering proximity to Sishane underground station, this property is located about 900 metres away.

Comprising a balcony and a sitting area, the rooms at the hotel are equipped with a flat-screen TV with satellite channels. Appointed with soundproof windows, the rooms also come with a minibar. They feature bathrooms with a walk-in shower and a separate toilet as well as a dryer and towels.

The restaurant 360 Istanbul is situated a stone's throw from Hotel Santa Beyoglu.