Located 3 km from the Basilica Cistern, Hotel Santa Beyoglu Istanbul is a 6-minute walk from Church of Saint Anthony of Padua.

This hotel lies in European Side with Istanbul's old center, with classic sights like opulent Topkapı Palace, the Blue Mosque, and Hagia Sophia, a mosque famed for its Byzantine mosaics in the vicinity of the Beyoglu. The 3-star hotel stands within 900 metres of the Hagia Triada Greek Orthodox Church. Guests might as well visit Palazzo Venezia, which is 12 minutes' walk away. The Santa Beyoglu is also just near the ancient Sultanahmet District and Tarlabasi bus station is about 500 metres away. This property is situated 10 minutes' stroll from Sishane underground station and 2.8 km from Sirkeci train station.

Comprising a balcony and a sitting area, the rooms at the hotel are equipped with a flat-screen TV with satellite channels. Appointed with sound-proof windows, the rooms also come with a minibar fridge. They feature bathrooms with a walk-in shower and a separate toilet as well as dryers and towels.

The restaurant 360 Istanbul is situated a few moments from Hotel Santa Beyoglu.