The 3-star Santefe Hotel Istanbul, located near the shopping district of Istanbul, offers air-conditioned rooms with Wi-Fi in public areas. This Istanbul hotel lies in European Side with Istanbul's old center, with classic sights like opulent Topkapı Palace, the Blue Mosque, and Hagia Sophia, a mosque famed for its Byzantine mosaics, about 20 minutes on foot from such cultural sights as the Serpent Column.

The byzantine basilica Hagia Sophia Museum is only 1.7 km from the hotel which is also just around the corner from the Istanbul Photography Museum. Beyazıt Square stands merely an 11-minute stroll from the Santefe Istanbul. Guests might as well enjoy proximity to Cundi Park, situated a mere 0.6 km away. The Basilica Cistern lies nearly a 25-minute walk away, while Vezneciler-İstanbul Üniversitesi tube station is not far from the accommodation. The Santefe is approximately 300 metres from Yenikapi Sahil bus stop and only 1.5 km from Sirkeci train station in Istanbul.

The rooms overlook the city and feature complimentary wireless internet and a television with satellite channels along with a minibar and an electric kettle. The rooms at this Istanbul hotel also offer traditional ottoman décor. Providing a separate toilet, some bathrooms have bath sheets.

Every morning, a free breakfast is served at the Santefe Istanbul. Guests can enjoy meals of European cuisine at Fener Restaurant KumkapI, situated steps away from the property.