The 2-star Serene Hotel Istanbul is situated in a prime touristic area of Istanbul, 2.4 km from the Basilica Cistern and around 25 minutes' walk from the Ottoman imperial New Mosque. Boasting a location fairly close to the Historical Galatasaray Bath, the hotel features 10 rooms as well as a storage room and a lobby area.

French Street is located 500 metres from this Istanbul hotel, and such natural sites as Miniaturk Miniature Park are 4.2 km away. The Serene stands in proximity to Sishane-Zemin Istanbul tube station. The accommodation is also within a 1-km distance of Republic Monument and Tarlabasi bus station is approximately a 10-minute walk away. The nearest underground station is merely 650 metres away.

The rooms at Serene Hotel include individual climate control and an iron. Some of them comprise a dining area and a kitchen, furnished with a writing desk. They come equipped with coffee and tea makers for self-catering along with complimentary wireless internet and a cable TV with on-demand films for business and leisure. Featuring a separate toilet and a shower, the bathrooms also come with hairdryers and bath sheets. The rooms also look out over the pool. Guests are welcome to use a kitchenette with a microwave oven, an electric kettle, and refrigerators in an apartment.

Van Kahvalti Evi is located next to the Serene Istanbul and serves Middle Eastern dishes, only a 5-minute stroll away.