Offering a convenience store and baggage storage, Sis Hotel Istanbul lies in Laleli, which is known by some as Istanbul's Russia Town, just 1.6 km from the 85m-tall Beyazit Tower and within 25 minutes' walk of such cultural places of interest as the neoclassical Istanbul Archaeology Museums. This Istanbul hotel features safety facilities including luggage storage.

Located just 1.8 km from Little Hagia Sophia Mosque, the hotel is also just near Yenikapi Aktarma Merkezi railway station. The Sis Istanbul offers proximity to natural sights like the historical urban Gulhane Park (2.3 km) and Miniaturk Miniature Park (7 km). The Holy mosque "Hagia Sophia Museum" is approximately a 30-minute walk away, and Yenikapi underground station is approximately 300 metres from the accommodation. This hotel stands within a 600-metre distance of the Ottoman imperial Pertevniyal Valide Sultan Mosque, right around the corner from Havaist Aksaray to Istanbul Airport bus stop.

Sis Hotel serves a delightful daily breakfast. Guests can enjoy a selection of Turkish dishes at Change Cafe & Pub situated a stone's throw from the property.