Offering a luggage room, the smoke-free Taksim Santa Lucia Hotel Istanbul lies in the entertainment Talimhane district, merely 1.4 km from Istanbul Riverside Museum of Modern Art and just 14 minutes' walk from the Museum of Innocence. Located approximately 25 minutes on foot from the Dolmabahce Palace, this Istanbul hotel features 20 rooms with views of the city.

The hotel is about 45 km from Istanbul airport and a mere 1.9 km from such cultural venues as The Quincentennial Foundation Jewish Museum of Turkish Jews. The Taksim Santa Lucia Istanbul is situated within 5 minutes' walk of the Republic Monument and not far from Taksim underground station. 350 metres from the property there is the cobblestone Istiklal Street. Omer hayyam bus stop is also nearly a 10-minute walk away.

All allergy-friendly rooms at the Taksim Santa Lucia are equipped with a TV with satellite channels along with a minibar fridge, tea and coffee making facilities for self-catering. Furnished with a wardrobe and a writing table, they also have soundproof windows. Guests will find hairdryers and bath sheets in bathrooms fitted with a separate toilet and a shower.

Middle Eastern cuisine is offered at Zubeyir Ocakbasi, situated in close proximity to Taksim Santa Lucia Hotel.