Nestled in Golden Horn, which is a natural harbour off the strait, Zero Otel & Suit Istanbul is a 25-minute walk from the Dolmabahce Palace.

This hotel is located within 500 metres of the Neve Shalom Synagogue, in close proximity to Sishane tube station. The Taksim Gezi Park lies a 20-minute walk away. The Zero Otel & Suit is also 2.9 km from the medieval Byzantine Greek Orthodox church "Kariye Mosque" and Karakoey bus station is 850 metres away. Guests will find themselves a 20-minute stroll from Sirkeci train station.

The restaurant 360 Istanbul is situated within a few blocks of this 4-star hotel.