Located nearly a 15-minute walk from the Ottoman Rustem Pasha Mosque, the 3-star smoke-free Seyri Istanbul Hotel includes 12 rooms. Featuring Wi-Fi throughout the property, the comfortable hotel also has amenities such as a storage for belongings.

The hotel is notable for its convenient location, only 600 m from the Storied 16th-century Suleymaniye Ottoman Mosque and within a few blocks of Sirkeci train station. The Ottoman - era Friday Blue Mosque is within 25 minutes' walk of the Seyri in Istanbul. Guests might as well enjoy proximity to Alfred Heilbronn Botanical Garden, situated 0.9 km away. The superb Istanbul Archaeology Museums is about 30 minutes' walk away, while Vezneciler-İstanbul Üniversitesi underground station is a stone's throw from this accommodation. Sehzadebasi bus stop is 300 metres from the Seyri Istanbul.

Along with free Wi-Fi and a flat-screen TV with satellite channels, the non-smoking rooms offer a mini-fridge-bar, tea and coffee making equipment, and private bathrooms with a separate toilet, a shower, and a sink. The private bathrooms include a separate toilet, a shower, and a sink. The rooms offer views of the river.

A buffet breakfast, with different food options, is offered each morning. Hamdi Restaurant is in the vicinity of Seyri Istanbul Hotel and specialises in Mediterranean cuisine.